Selected Publications
Metastatic competency and tumor spheroid formation are independent cell states governed by RB in lung adenocarcinoma
Nelson F. Freeburg, Nia Petersen, Dan A. Ruiz, Amy C. Gladstein, and David M. Feldser. Cancer Research Communications. Cancer Res Commun. 2023 Sep 20. doi: 10.1158/2767-9764.CRC-23-0172. Online ahead of print.PMID: 37728504
p53 restoration in small cell lung cancer identifies a latent cyclophilin-dependent necrosis mechanism
Jonuelle Acosta, Qinglan Li, Nelson F. Freeburg, Nivitha Murali, Grant P. Grothusen, Michelle Cicchini, Hung Mai, Amy C. Gladstein, Keren M. Adler, Katherine R. Doerig, Jinyang Li, Miguel Ruiz-Torres, Kimberly L. Manning, Ben Z. Stanger, Luca Busino, Liling Wan, David M. Feldser. Nature Communications. 2023 Jul 21;14(1):4403. doi: 10.1038/s41467-023-40161-9. PMID: 37479684
Setd2 inactivation sensitizes lung adenocarcinoma to inhibitors of oxidative respiration and mTORC1 signaling
David M. Walter, Amy C. Gladstein, Katherine R. Doerig, Ramakrishnan Natesan, Saravana G. Baskaran, A. Andrea Gudiel, Keren M. Adler, Jonuelle O. Acosta, Douglas C. Wallace, Irfan A. Asangani, David M. Feldser. Communications Biology. 2023 Mar 10;6(1):255. doi: 10.1038/s42003-023-04618-3. PMID: 36899051
PKC epsilon is required for KRAS-driven lung tumorigenesis
Garg R, Cooke M, Benavides F, Abba MC, Cicchini M, Feldser DM, Kazanietz MG. Cancer Res. 2020 Sep 29:canres.1300.2020. doi: 10.1158/0008-5472.CAN-20-1300. Epub ahead of print. PMID: 32994205.
RB constrains lineage fidelity and multiple stages of tumour progression and metastasis
Walter DM, Yates TJ, Ruiz-Torres M, Kim-Kiselak C, Gudiel AA, Deshpande C, Wang WZ, Cicchini M, Stokes KL, Tobias JW, Buza E, Feldser DM. Nature. 2019 May;569(7756):423-427. doi: 10.1038/s41586-019-1172-9. Epub 2019 May 1. PMID: 31043741
Natural killer cells limit the clearance of senescent lung adenocarcinoma cells
Stokes, K, Acosta, J, Lauderback, B, Robles-Oteiza, C, Cicchini, M and Feldser, D.M. Oncogenesis. 2019 Apr 1;8(4):24. doi: 10.1038/s41389-019-0133-3. PMID: 30936429
Off and Back-On Again: A Tumor Suppressor’s Tale
Acosta J, Wang W, and Feldser DM (2018). Oncogene. 2018 Mar 15. doi: 10.1038/s41388-018-0186-3. [Epub ahead of print] Review. PMID: 29540833
Systematic in vivo inactivation of chromatin regulating enzymes identifies Setd2 as a potent tumor suppressor in lung adenocarcinoma
Walter DM, Venancio OS, Buza EL, Tobias JW, Deshpande C, Gudiel AA, Kim-Kiselak C, Cicchini M, Yates TJ, and Feldser DM (2017). Cancer Research. 2017 Feb 15. pii: canres.2159.2016. doi: 10.1158/0008-5472.CAN-16-2159. [Epub ahead of print]. PMID: 28202515
Context dependent effects of amplified MAPK signaling during lung adenocarcinoma initiation and progression.
Cicchini M, Buza E.L., Sagal K.M., Gudiel A.A., Durham A.C., and Feldser DM (2017). Cell Reports. 2017 Cell Reports.2017 Feb 21;18(8):1958-1969. PMID: 28228261
XTR: A recombinase-based system for regulating gene function in a conditional and reversible manner
Robles-Oteiza C, Taylor SE, Yates T, Cicchini M, Lauderback B, Cashman C, Burds AA, Winslow M, Jacks T, Feldser DM (2015). Nature Communications. 2015 Nov 5;6:8783. PMID: 26537451
Stage-specific sensitivity to p53 restoration during lung cancer progression
Feldser DM, Kostova KK, Winslow MM, Taylor SE, Cashman C, Whittaker CA, Sanchez-Rivera FJ, Resnick R, Bronson R, Hemann MT, Jacks T. Nature. 2010 Nov 25;468:572-5. PMID: 21107428; PubMed Central PMCID: PMC3003305.